Generic Name: Aminoguanidine
Brand Name: AgmaSet, Agmatine Sulfate
Dosage Forms: Oral
What is Agmatine?
Agmatine is a naturally occurring amino acid metabolite synthesized in humans, animals, and plants. Our central nervous system transmits impulses that cause a release of neurotransmitter molecules from the nerve axon. The neurotransmitters lead to excitation or inhibition of the target neuron. Endogenous Agmatine modulates several of these neurotransmission pathways.1
Functions of Agmatine specific to CNS include(s):
– Modulation of chemical and electrical pathways
– Regulation of cell repair
– Learning and memory effects
– Release of pain-reducing endorphins from the pituitary gland
Studies have shown a relationship between abnormal Agmatine neurotransmission and the disease process of psychiatric conditions. Injury and inflammation in the CNS trigger the release of Agmatine into synaptic clefts. This neuroprotective property of Agmatine is being analyzed to determine its efficacy in the treatment of numerous CNS abnormalities such as:
– A broad range of mental illnesses like anxiety, depression, and psychosis (schizophrenia, bipolar disorder)
– Neurodegenerative diseases (e.g., dementia, Alzheimer’s)
– Neuropathic pain such as postherpetic neuralgia, Bell’s Palsy, etc.,
Other uses of Agmatine include:
– Reduced heart rate and blood pressure
– Increased insulin release from the pancreas, which might cause hypoglycemia
Based on its effects on systems other than CNS, Agmatine is sometimes indicated for:
– Decrease in kidney function
How to Use Agmatine?
Research conducted on the effect of Agmatine on reducing neuropathic pain established that Agmatine could be safely administered for up to 3 weeks. However, there is still a need for more data to support the use of Agmatine as a nutraceutical. 2
Therefore, Agmatine should not be purchased as an over-the-counter supplement. Consult with your doctor if you are looking into treatment with Agmatine. It is available as an encapsulated gelatin capsule that is taken orally with water. The preferred time for intake is after morning and evening meals.
What Are the Side Effects of Agmatine?
A 5-year study on the effects of approved high daily dosage of Agmatine claimed that no adverse reactions were reported during research. Even then, medical research experts recommend vulnerable groups to avoid the intake of Agmatine without consultation.
Side effects are the same as those with any nutritional supplement. Nausea and stomach upset are the most common among them.
Who Should Not Use Agmatine?
Even though adverse effects with Agmatine have not been reported, vulnerable groups are especially discouraged from taking medications or supplements without consultation with a doctor.
These vulnerable groups are classified as:
– Pregnant women
– Breastfeeding mothers
– Immunocompromised patients
– Those undergoing cancer therapy
– Patients with co-morbidities
– Patients with diabetes
– Those prone to low blood sugar and blood pressure
- Xu W, Gao L, Li T, Shao A, Zhang J. Neuroprotective Role of Agmatine in Neurological Diseases. Curr Neuropharm. 2018;16(9):1296-1305. DOI: 10.2174/1570159X15666170808120633
- Gad M. Gilad and Varda H. Long-Term (5 Years), High Daily Dosage of Dietary Agmatine—Evidence of Safety: A Case Report. Gilad J Med Food. 2014; 17(11):1256-1259. DOI: https://doi.org/10.1089/jmf.2014.0026