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Generic Name: Maprotiline Hydrochloride

Brand Names: Ludiomil

Drug Class: TCA

Similar Class Drugs: Amitriptyline, Protriptyline

Available Dosage Form: Oral tablet

Maprotiline: Uses, Side effects. Ludiomil
Courtesy: Unsplash

What is Maprotiline?

The FDA authorizes Maprotiline for the treatment of:

– Major depressive disorder

– Depression associated with manic episodes

– Anxiety as a symptom of depression

– Chronic depression

It has the highest affinity for inhibiting the uptake of norepinephrine. A surge in the concentration of norepinephrine diminishes the symptoms of depression and anxiety. Maprotiline induces pronounced antihistaminic and moderate anticholinergic effects.

Impaired memory is a common side effect. It is critical to differentiate the symptoms of “pseudodementia” precipitated by the long-term use of Maprotiline from those of neurodegenerative disease dementia. Thorough medication history aids in ruling out the possibility of the disease. 1


How to use Maprotiline?

– If you are diagnosed with mild to moderate depression, your doctor might start treatment with the dosage of 75mg

– The initial dosage is 25 mg in older patients

– Oral tablets are film-coated

– Break the tablet along the score line if your doctor asks you to divide the dosage

– You will start to feel better in 2-3 weeks if you have taken your doses timely

– Your doctor will change your dosage regime according to the stage of treatment


What are the side effects of Maprotiline?

– Blurred vision, headache, dizziness, insomnia, impaired memory, syncope, tremors

– Constipation, nausea

– Palpitations, orthostatic hypotension

Life-threatening adverse effects:

– Arrhythmias, heart block

– Suicidal behavior

– Worsening of mania

– Sexual impairment

Negative effects on the metabolism have been documented with Maprotiline.2 It increased serum ghrelin levels, a hormone involved in appetite and weight gain. The results concluded that Maprotiline is strongly associated with causing weight gain and raised BMI.


Who should not use Maprotiline?

– Patients with susceptibility to seizures

– Patients with hypersensitivity to the drug

– Patients taking MAOIs

– Patients in the acute recovery period of myocardial infarction



  1. Pinar M, Gulsun M, Tasci I, et al. Maprotiline induced weight gain in Depressive DISORDER: Changes in CIRCULATING ghrelin and adiponectin levels and insulin sensitivity. Progress in Neuro-Psychopharmacology and Biological Psychiatry. Published Aug 8, 2007. Accessed Aug 7, 2021.
  1. Vinader-Carols C, Martos AJ, Monleón S, Arenas MC, Parra A. Acute effects of Maprotiline on learning, anxiety, activity, and analgesia in male and female mice. Acta neurobiologiae experimentalis. Available from: Published 2006 Jan 1. Accessed Aug 7, 2021

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