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Generic Name: Trimipramine Maleate

Brand Names: Trimip, Surmontil

Drug Class: Tricyclic antidepressants (TCAs)

Similar Class Drugs: Amitriptyline, Amoxapine

Available Dosage Form: Oral capsule

Trimipramine: Uses, Side effects. Trimipramine Maleate
Courtesy: Unsplash

What is Trimipramine?

Trimipramine belongs to a class of medications known as TCAs, which are used as antidepressants. It relieves symptoms of depression and contains an anxiety-reducing sedative component in its action.

It is prescribed for the following FDA approved indications:

– Depression with endogenous cause

– Neurotic depression in people with unstable mood

– Depressed hospitalized patients

Trimipramine is more likely to ease endogenous depression than other states of depression. However, trimipramine (TCA) is no longer the first line of treatment to treat depression. SSRIs, SNRIs, and newer agents are preferred for broad safety profiles and therapeutic efficacy today.


How to use Trimipramine?

Trimipramine is available as capsules in doses of 20, 50, and 100 mg generically. Initial dosages depend on the severity of the condition. The most commonly prescribed initial dosage for adult outpatients and office patients is 75 mg/day in divided doses, increasing to as high as 150 mg/day based on its efficacy and tolerance.

The initial dosage for hospitalized patients is 100 mg/day in divided doses, gradually increasing to 200 mg/day in a few days based on individual tolerance and response. The dosage may increase to the maximum recommended dose of 250 mg/day to 300 mg/day if there is no improvement in 2 to 3 weeks.

The initial dosage for adolescent patients is 50 mg/day, gradually increasing to 100 mg/day.

The lowest dosage is given for maintenance therapy following remission. It is given as a single dose at bedtime and usually continues for three months to minimize relapse.


What are the side effects of Trimipramine?

Trimipramine induces side effects that are common with other TCAs as well. These side effects include:1

– Diarrhea

– Nausea

– Vomiting

– Lethargy

– Drowsiness

– Headache

– Insomnia

– Weight gain

– Sexual impairment

Rare potential adverse effects include:1

– Suicidal risk

– Arrhythmias

– Urinary retention

– Serotonin syndrome


Who should not use Trimipramine?

– Anyone that doesn’t have a prescription

– Anyone that is hypersensitive to TCAs.

– Anyone taking Monoamine Oxidase Inhibitors (MAOIs), using Trimipramine within 14 days of stopping an MAOI, or using an MAOI within 14 days of stopping treatment with Trimipramine.

– Anyone who is recovering from myocardial infarction (heart attack).



  1. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Trimipramine. [Updated 2020 Apr 5].Available from:
  2. Available from: [Updated: 2016 Jan 19]. Accessed August 28, 2021

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